In the context of an increasing interest in mindfulness-based approaches both in clinical application as well as in the field of research the present paper introduces MBSR (Mindfulness-based Stress Reduction), illustrates the theoretical background of mindfulness practice and reviews the procedures during the cultivation of mindfulness and possible impacting factors. The article also reviews Mindfulness-based Cognitive Therapy (MBCT), which was specifically developed to prevent relapse in patients with depressive disorders. The paper ends with a conclusion for clinical practice.