The aim of this study was to determine the association between color perception determined by maximum color contrast sensitivity and Farnsworth-Munsell 100-hue tests and visual acuity in the presence of optic nerve disk drusen.A case-control study, including 137 persons, was performed. Thirty-seven patients (67 eyes) with optic nerve disk drusen and 100 healthy controls (200 eyes) were examined. For visual acuity testing, a typical Snellen chart (the direction of the gap in Landolt C) was used. A computerized Farnsworth-Munsell 100-hue test and maximum color contrast sensitivity programs were used for color discrimination.The results of maximum color contrast sensitivity test, and the Farnsworth-Munsell 100-hue test were better in healthy controls than patients (1.94 ± 0.66 vs. 2.2 ± 0.85, P=0.02; 94.1 ± 53.9 vs. 120.6 ± 61, P=0.003, respectively).The study revealed that the presence of optic nerve disk drusen was associated with decreased perception of colors.