Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects.
Copyright policy Cytotoxic chemotherapy-induced second primary neoplasms: clinical aspects.
The incidence of second malignancies was assessed by retrospectively analyzing data from previous studies in well-defined and closely followed patient cohorts. After a median follow-up of more than 6 years following MOPP (mechlorethamine/vincristine/procarbazine/prednisone) chemotherapy with or without radiotherapy, 5% of patients with Hodgkin's disease developed second primaries, 60% of which were leukemias. Melphalan caused a 3% leukemia rate among 1129 patients with ovarian cancer who were followed for a median period of 4 years. No leukemia was observed among 1132 breast cancer patients treated with adjuvant CMF (cyclophosphamide/methotrexate/5-fluorouracil) after a median follow-up of 7.5 years. Long-term, comprehensive studies are needed to improve the current knowledge and the prognosis of patients with second primary neoplasms.
- University of Graz Austria
Ovarian Neoplasms, Leukemia, Antineoplastic Agents, Breast Neoplasms, Hodgkin Disease, Neoplasms, Multiple Primary, Vincristine, Procarbazine, Antineoplastic Combined Chemotherapy Protocols, Humans, Prednisone, Female, Mechlorethamine, Melphalan, Randomized Controlled Trials as Topic, Retrospective Studies
Ovarian Neoplasms, Leukemia, Antineoplastic Agents, Breast Neoplasms, Hodgkin Disease, Neoplasms, Multiple Primary, Vincristine, Procarbazine, Antineoplastic Combined Chemotherapy Protocols, Humans, Prednisone, Female, Mechlorethamine, Melphalan, Randomized Controlled Trials as Topic, Retrospective Studies
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