Flaveria bidentis (Asteraceae), a potential exotic invasive weed to agro-ecosystem and rangeland ecosystem, has recently invaded Tianjin City and Hebei Province (Hengshui and Langfang) in North China, and is spreading further. Based on its current geographical distribution in the world, the potential distribution areas of this weed in China were predicted by using CLIMEX software, aimed to assess the potential risks of this invasive weed. Following provinces in China could be the potential areas being invaded by F. bidentis, i. e., Guangdong, Guangxi, Yunnan, Hainan, Fujian, Taiwan, Jiangxi, Hunan, Guizhou, Sichuan, Chongqing, Hubei, Anhui, Jiangsu, and Shanghai, among which, Guangdong, Guangxi, Taiwan, Hainan, Fujian, Yunnan, Sichuan, Guizhou, Chongqing, and part of Xizang would be at high risk.