Overcoming inhibition in the spindle checkpoint.
Copyright policy )Overcoming inhibition in the spindle checkpoint.
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
Medicine(all), Gene Expression Regulation, Fungal, Protein Phosphatase 1, Yeasts, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Spindle Apparatus, /dk/atira/pure/subjectarea/asjc/2700, Kinetochores, Models, Biological, Signal Transduction
Medicine(all), Gene Expression Regulation, Fungal, Protein Phosphatase 1, Yeasts, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Spindle Apparatus, /dk/atira/pure/subjectarea/asjc/2700, Kinetochores, Models, Biological, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).24 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!