Tribocorrosion covers the material degradation process resulting from the combined interaction of wear and corrosion phenomena on surfaces subjected to a relative contact movement. Bio-tribocorrosion is the designation used to describe the tribocorrosion behavior of materials in contact with biological environments, as it happens with instruments used in the medical field and devices inserted in the human body. Under in vivo conditions, a complex tribological contact may be formed in orthopedic and dental implants in association with a chemical and biological aggressive environment. Consequently, wear debris and corrosion products or ions can lead to inflammatory reactions, such as osteolysis (bone resorption), provoking bone loss and subsequent loosening of the implant/prosthesis. An overview of the aspects intervening on the tribocorrosion and biotribocorrosion of biomaterials is given in this chapter, with a particular focus on the topics related with the oral environment and dental implants, especially those built in titanium. These implants are under a complex congregation of mechanical solicitations and chemical aggressive substances, which can change considerably in magnitude or nature over the day and between individuals. Moreover, the interaction with cells, particularly with microorganisms, will result in local modification of the surrounding environment, both from the chemical and mechanical points of view. Biotribocorrosion response will depend on the multifaceted combination of all those factors. This review gathers knowledge from distinct fields such as materials sciences, microbiology, and dentistry, aiming at contributing to a better understanding of bio-tribocorrosion processes in the oral environment.