In ours days we are watching an increasing demand for highly differentiated products with a significant added value, that simultaneously consider issues such as easy to use, comfort, flexibility in wearing and fashionable look. In this group of products are the multifunctional fashion clothing’s. These products allow different uses in different scenarios, such as adaptation to diverse social situations, weather conditions, etc. The present paper looks at the key elements in the development of multifunctional concepts, proposing their integration in a design methodology for the development of multifunctional textile fashion products. We also present a couple of academic projects that support the proposed methodology.