The rising prevalence of food allergies poses an increasingly important clinical problem.Peanut is one of the most potent allergens, and allergic reactions to peanuts may even be fatal.A great proportion of hypersensitive individuals manifest allergic reaction on their first exposure to peanut containing food, pointing to pre-existing sensitization. Therefore, the question arises whether peanut containing topical preparations are safe or epicutaneous sensitization is still possible. In conclusion, peanut sensitization is an important and increasing clinical problem due to the severe allergic manifestations that may threaten the life of sensitized individuals. Topical preparations containing peanut oil have proved efficient in the treatment of very dry and damaged skin in children and adults with atopic diseases. Epicutaneous sensitization is one of the potential routes of sensitization ; therefore great caution is warranted in individuals with allergic predisposition.