In the conditions of denatured natural environment, rather complex ecological setting and constant deterioration of the health and demographic state of the population, the working out gives: a formulation of a new methodical approach to evaluating the interaction "environment--health", reporting its multifactor stimulation; the basic features of the characteristics of the local health and demographic potential of the population in the country in territory aspect according to the introduced indices: local health potential (LHP), local demographic potential (LDP) and territorial health index (THI) with underlined negative tendencies in their changes, traced in dynamics; the argumentation of the necessity for introducing health and demographic criteria and carrying out policy for determining the ecological risk in solving the problems, related to the evaluation and improvement of the conditions of the urbanized environment. Ecologic-appropriate development of the settlement environment could not achieve its purpose, without the formulation and action of criteria, allowing the evaluation and control of its effectiveness in conformity with the basic health interests of the inhabitants.