The aim of the study was to identify the motor structures that determine achievement of top results in karate. The study included a sample of 85 karateka aged 18-29 years, competing as senior category athletes of the Croatian Karate Society. Fourteen motor tests (9 basic motor tests and 5 specific motor tests) were used to assess technical efficiency; fighting efficiency was estimated on the basis of results achieved at a number of contests. Factorial analysis of the basic set of motor variables indicated the presence of three major factors of coordination, explosive strength, and movement frequency. Factorial analysis of pooled basic and specific motor variables also pointed to three major factors of speed (basic and specific), controlled power (explosive strength and specific agility), and basic coordination. Regression analysis showed the isolated basic factors to significantly determine both technical and fighting efficiency of the karateka, with the major role of the factor of explosive strength (power). Regression analysis of pooled basic and specific factors revealed the factors of controlled speed and controlled power to predominantly determine the karateka fighting and technical efficiency. In the set of tests used to assess specific motor abilities in karate, the speed of blockade, the speed of moving in multiple directions, and frequency of foot kicking were found to be the best predictors of technical efficiency, whereas the speed of moving in multiple directions, the speed of blockade, and frequency of foot kicking were the best predictors of fighting efficiency.