Alpha-lipoic acid, an anti-obesity agent?
Copyright policy )Alpha-lipoic acid, an anti-obesity agent?
Obesity shortens life expectancy and is a risk factor for hypertension and Type 2 diabetes. When added to the standard chow of Sprague-Dawley or Otsuka Long-Evans Tokushima Fatty rats, alpha-lipoic acid (0.5% weight/weight) reduced body weight and food intake. Alpha-lipoic acid also increased whole-body energy expenditure. It exerts its effects by suppressing hypothalamic AMP-activated protein kinase. Long-term studies to determine whether these anti-obesity effects are maintained in animals are required before alpha-lipoic acid is considered for clinical trial in human obesity.
- University of Queensland Australia
- University of Queensland Australia
α-lipoic acid, Thioctic Acid, Rats, Inbred OLETF, AMP-Activated Protein Kinases, Protein Serine-Threonine Kinases, Lipid Metabolism, Body-weight, Metformin, Rats, Rats, Sprague-Dawley, Disease Models, Animal, 3004 Pharmacology, Multienzyme Complexes, AMP-activated protein kinae, Animals, Humans, Otsuka Long-Evans Tokushima Fatty rats, Anti-Obesity Agents, Obesity
α-lipoic acid, Thioctic Acid, Rats, Inbred OLETF, AMP-Activated Protein Kinases, Protein Serine-Threonine Kinases, Lipid Metabolism, Body-weight, Metformin, Rats, Rats, Sprague-Dawley, Disease Models, Animal, 3004 Pharmacology, Multienzyme Complexes, AMP-activated protein kinae, Animals, Humans, Otsuka Long-Evans Tokushima Fatty rats, Anti-Obesity Agents, Obesity
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