Regulation of WASP: PIP2 Pipped by Toca-1?
Copyright policy )Regulation of WASP: PIP2 Pipped by Toca-1?
Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.
- University of Birmingham United Kingdom
- College of New Jersey United States
Phosphatidylinositol 4,5-Diphosphate, Cell Movement, Animals, Cell Polarity, Humans, Proteins, cdc42 GTP-Binding Protein, Actins, Wiskott-Aldrich Syndrome Protein, Protein Binding, Protein Structure, Tertiary, Signal Transduction
Phosphatidylinositol 4,5-Diphosphate, Cell Movement, Animals, Cell Polarity, Humans, Proteins, cdc42 GTP-Binding Protein, Actins, Wiskott-Aldrich Syndrome Protein, Protein Binding, Protein Structure, Tertiary, Signal Transduction
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