The adaptation of whitebacked planthopper (WBPH) Sogatella furcifera to insect-resistant rice variety N22 and the variation of its protective enzyme were studied by rearing it successively two generations on N22 and insect-susceptible rice variety TN1 in laboratory. The results showed that after reared on TN1 or N22 for one or two generations, its egg period, nymphal duration, and total generation period had no significant difference. The ecological parameters, e.g., nymphal survival rate, body weight, amount of honey dew, egg number, and innate increasing rate of WBPH transferred from TN1 to N22 and reared for one generation were lower than those of WBPH reared on N22 successively for two generations, and the latter was lower than that reared on TN1. The activities of superoxide dismutase (SOD) and catalase (CAT) in protective enzyme system of the 2nd generation WBPH on N22 were similar to those of the pest on TN1, indicating that S. furcifera could adapt to insect-resistant variety N22 after rearing it successively for several generations.