
Recurrent event data typically exhibit the phenomenon of intra-individual correlation, owing to not only observed covariates but also random effects. In many applications, the population may be reasonably postulated as a heterogeneous mixture of individual renewal processes, and the inference of interest is the effect of individual-level covariates. In this article, we suggest and investigate a marginal proportional hazards model for gaps between recurrent events. A connection is established between observed gap times and clustered survival data with informative cluster size. We subsequently construct a novel and general inference procedure for the latter, based on a functional formulation of standard Cox regression. Large-sample theory is established for the proposed estimators. Numerical studies demonstrate that the procedure performs well with practical sample sizes. Application to the well-known bladder tumor data is given as an illustration.
Reliability and life testing, renewal process, proportional hazards model, semiparametric inference, partial score, Estimation in survival analysis and censored data, clustered survival data, Survival Analysis, Applications of statistics to biology and medical sciences; meta analysis, Urinary Bladder Neoplasms, Recurrence, estimating equation, Cluster Analysis, Humans, Regression Analysis, Proportional Hazards Models
Reliability and life testing, renewal process, proportional hazards model, semiparametric inference, partial score, Estimation in survival analysis and censored data, clustered survival data, Survival Analysis, Applications of statistics to biology and medical sciences; meta analysis, Urinary Bladder Neoplasms, Recurrence, estimating equation, Cluster Analysis, Humans, Regression Analysis, Proportional Hazards Models
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 45 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
