Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

Melanie J, Calvert; Susan E, Taylor; Rudolf K, Allemann

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Chemical Communicati...arrow_drop_down

Chemical Communications

Article . 2003

Data sources: Europe PubMed Central

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

descriptionPublicationkeyboard_double_arrow_right Article 12 Aug 2003 English Journal:Chemical communications (Cambridge, England) (issn: 1359-7345,

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Authors: Melanie J, Calvert; Susan E, Taylor; Rudolf K, Allemann;

pmid: 12430452

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

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Abstract

A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic beta-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS.

Related Organizations

University of Birmingham
United Kingdom

Keywords

Amino Acid Substitution, Polyisoprenyl Phosphates, Cyclization, Mutagenesis, Site-Directed, Tyrosine, Isomerases, Sesquiterpenes, Gas Chromatography-Mass Spectrometry

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