[Expression analysis of protein tyrosine kinases of the FAK (focal adhesion kinase) family in osteosarcoma].
Copyright policy )[Expression analysis of protein tyrosine kinases of the FAK (focal adhesion kinase) family in osteosarcoma].
Expression analysis of the protein tyrosine kinases, focal adhesion kinase (FAK) and proline-rich tyrosine kinase2 (Pyk2) in high grade osteosarcomas.Expression of the kinases was evaluated qualitatively by immunohistochemical staining and quantitatively by real-time PCR.Osteoblastic cells of high grade osteosarcomas show a distinct FAK expression but an overexpression at the transcriptional level could not be detected. The Pyk2-mRNA expression was decreased in osteosarcomas.An altered relationship of FAK and Pyk2 was observed for different tumors and could also be important for osteosarcoma development.
- Pathologisches Institut Germany
- Universität Hamburg Germany
Adult, Male, Osteosarcoma, Adolescent, Bone Neoplasms, Middle Aged, Protein-Tyrosine Kinases, Immunohistochemistry, Polymerase Chain Reaction, Child, Preschool, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Humans, Female, Child, Aged
Adult, Male, Osteosarcoma, Adolescent, Bone Neoplasms, Middle Aged, Protein-Tyrosine Kinases, Immunohistochemistry, Polymerase Chain Reaction, Child, Preschool, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Humans, Female, Child, Aged
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