Three outbreaks of hepatogenous photosensitization caused by pods of Enterolobium contortisiliquum are reported in cattle. Clinical signs were anorexia, depression, photosensitization and abortion. Most affected cattle recovered in 30-40 d. At necropsies, liver was present, the gallbladder was enlarged and edematous, and numerous seeds of E contortisiliquum were in the forestomachs and abomasum. Fruits of the plants administrated to 2 calves produced clinical signs and 2/4 died. Clinical chemistry, gross necropsies and histopathology confirmed gastrointestinal irritation and liver degeneration. One calf dosed with only E contortisiliquum leaves did not develop clinical signs.