Previous research has indicated that adolescents' relationships with their mother influence their academic expectations and achievement. Substance use has also been found to have a strong influence on academic expectations and achievement. In the present study, 80 high school seniors from middle to upper socioeconomic status families completed questionnaires on behavioral and psychological aspects of adolescent life. Academic expectations were found to be highly correlated with academic achievement (r = .60). A stepwise regression analysis revealed that relationship with mother, academic achievement, and alcohol use accounted for 56% of the total variance in academic expectations. Stepwise regression on academic achievement revealed that cocaine use, marijuana use, and academic expectations accounted for 48% of the total variance.