The Carthaginian presence in northern Coastal Etruria is well documented, being part of a longstanding tradition of hospitality and political and economic ties between Etruscans and Punics. Indeed, and particularly for the Hellenistic period, specific artefacts and epigraphic data even testify to the permanent presence of Carthaginians in Populonia and Pisa, attracted to and directly involved in the mercantile activity and the mining industry. Punic amphorae are undoubtedly a key indicator of this network of commercial relationships. Still, while documentation is consistent for the middle and late Hellenistic periods, evidence is sparser and more fragmentary for the previous centuries. Moreover, this geographical context lacks substantial archaeometric studies focused on this type of container. Recent acquisitions from Pisa, an Etruscan city since its earliest origins, help fill this gap with new data on Punic amphorae from a chronological and quantitative perspective. These findings reveal an uninterrupted presence from Orientalizing to the late Hellenistic period, with a noteworthy concentration between the end of the 5th and the middle of the 1st century BC. This article presents the outcomes of archaeometric analyses conducted on a set of Phoenician-Punic amphorae discovered in Pisa. The study highlights a plurality of production areas in the central-western Mediterranean. Specifically, fabrics from Carthage, North Africa, Western Sicily, the Balearic Islands, Sardinia and the southern coast of the Iberian Peninsula have been identified for the Hellenistic period.