The aim of our study was to investigate the inhibitory effect of black tea onCC4 (1 ml/kg, i.p.) induced lipid peroxidation bearing in mind sexual differencesbetween the animals. In addition the effect of CCl4 in causing hepatic injury byinducing lipid peroxidation was examined, again bearing in mind sexual differences.`Control`, `CCI4 ` and `Black Tea+CCI4 ` groups were made up from both maleand female rats. The rats in the `Black Tea+CCI4 ` group were fed the basal dietwith 6% black tea for 2 months. The rats in the `Control` group were treated witholive oil and the rats in the two other groups were treated with CCI4. They werekilled 2 hours after these treatments. Their plasma AL T and AST activities weremeasured by auto analyzer. Plasma and liver lipid peroxide levels were measured bythiobarbituric acid test. Liver glutathione levels were measured by the Ellman'smethod.According to our investigations, CCl4 treatment caused significant increasesin plasma AL T and AST activities and liver lipid peroxide levels in males andfemales, but CCl4 treatment did not cause a significant increase in plasma lipidperoxide levels under experimental conditions. A significant increase in glutathionelevels in males was observed, but a significant difference in females was notdetermined under experimental conditions. These findings showed that CCl4 causedhepatic injury and induced lipid peroxidation in liver both in males and females, butthis lipid peroxidation was not detected in plasma under experimental conditions. Itwas considered that an increase in glutathione level in males in response to lipidperoxidation in liver, was earlier than that in females.Black tea caused significant differences in neither the plasma lipid peroxidelevels of males nor of females but it significantly decreased liver lipid peroxide levelsin CCl4 treated males and females. In addition to that black tea showed a decreasingeffect in ALT, AST activities and in the light of these findings it was suggested thatblack tea lessened the hepatic injury.Black tea decreased the glutathione level in CCl4 treated males. As a result ofthis finding, it was speculated that black tea may have decreased the lipid peroxidelevel in liver and in response to this decrease the glutathione level remained low. Infemales, no significant difference was observed in glutathione levels. Also, whenmales and females in the `Control` group were compared, it was observed that therewere no significant differences between their lipid peroxide levels. However,glutathione levels in females compared to males were significantly lower. In the lightof this finding it was concluded that the glutathione level which was already lower infemales than in males did not fall further under experimental conditions.

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