The development of Tilletia caries on embryogenic and morphogenic wheat calluses from germination of spores up to sorus formation have been investigated. Pathogene growth was similar in variants with wheat calluses of susceptible species Triticum aestivum and resistant species T. timopheevii, but intensity of its development of embryogenic calluses of both species was lower, than on morphogenic. Necrosis of parenchyma-like cells was more distinct in the embryogenic than in morphogenic calluses. It was combined with low accumulation rate of infected cells in embryogenic calluses. Necrosis reduced the healthy cell reproduction in meristem-like cells of morphogenic calluses and thereby additionally decreased resistance of morphogenic calluses to pathogene.