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Optimal control and mathematical models in epidemiology

Authors: Paião, Ana Pedro Lemos;

Optimal control and mathematical models in epidemiology

Abstract

Nesta tese de doutoramento, provamos condições suficientes de otimalidade para problemas de controlo ótimo com tempos de atraso, transformando-os em problemas equivalentes sem tempos de atraso. Tal transformação é feita considerando uma técnica proposta por Guinn em 1976 e mais tarde promovida por Maurer e seus colaboradores. Deste modo, somos capazes de usar condições suficientes de otimalidade conhecidas para problemas de controlo ótimo sem tempos de atraso e voltar aos que consideram tempos de atraso. Propomos e estudamos vários modelos que traduzem a propagação da cólera e que consideram diferentes tipos de tratamento ou de medidas de prevenção. Problemas de controlo ótimo correspondentes são formulados e estudados. Tais análises teóricas são depois aplicadas a epidemias de cólera reais que ocorreram no Haiti e no Iémen.

In this PhD thesis, we prove sufficient optimality conditions for delayed optimal control problems, by transforming them into equivalent non-delayed problems. Such transformation is done by considering a technique proposed by Guinn in 1976 and later promoted by Maurer and his collaborators. In this way, we are able to use well-known sufficient optimality conditions for non-delayed optimal control problems and to return to the delayed ones. We propose and study several models that can translate the spread of cholera and that consider different types of treatment or prevention measures. Corresponding optimal control problems are formulated and studied. Such theoretical analysis are then applied to real cholera outbreaks that occured in Haiti and Yemen.

Programa Doutoral em Matemática Aplicada

Country
Portugal
Related Organizations
Keywords

Time delays, Local asymptotic stability, Sufficient optimality conditions, Mathematical models for cholera transmission, Optimal control

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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