The emergence of direct current (DC) microgrids within the context of residential buildings and offices brings in a whole new paradigm in energy distribution. As a result, a set of technical challenges arise, concerning the adoption of efficient, cost-effective, and reliable DC-compatible power conditioning solutions, suitable to interface DC microgrids and energy consuming elements. This thesis encompasses the development of DC–DC power conversion solutions, featuring improved availability and efficiency, suitable to meet the requirements of a comprehensive set of end-uses commonly found in homes and offices. Based on the energy consumption profiles and requirements of the typical elements found at homes and offices, three distinctive groups are established: light-emitting diode (LED) lighting, electric vehicle (EV) charging, and general appliances. For each group, a careful evaluation of the criteria to fulfil is performed, based on which at least one DC–DC power converter is selected and investigated. Totally, a set of five DC–DC converter topologies are addressed in this work, being specific aspects related to fault diagnosis and/or fault tolerance analysed with particular detail in two of them. Firstly, mathematical models are described for LED devices and EV batteries, for the development of a theoretical analysis of the systems’ operation through computational simulations. Based on a compilation of requirements to account for in each end-use (LED lighting, EV charging, and general appliances), brief design considerations are drawn for each converter topology, regarding their architecture and control strategy. Aiming a detailed understanding of the two DC–DC power conversion systems subjected to thorough evaluation in this work – interleaved boost converter and fault-tolerant single-inductor multiple-output (SIMO) converter – under both normal and abnormal conditions, the operation of the systems is evaluated in the presence of open-circuit (OC) faults. Parameters of interest are monitored and evaluated to understand how the failures impact the operation of the entire system. At this stage, valuable information is obtained for the development of fault diagnosis strategies. Taking profit of the data collected in the analysis, a novel fault diagnostic strategy is presented, targeting interleaved DC–DC boost converters for general appliances. Ease of implementation, fast diagnostic and robustness against false alarms distinguish the proposed approach over the state-of-the-art. Its effectiveness is confirmed through a set of operation scenarios, implemented in both simulation environment and experimental context. Finally, an extensive set of reconfiguration strategies is presented and evaluated, aiming to grant fault tolerance capability to the multiple DC–DC converter topologies under analysis. A hybrid reconfiguration approach is developed for the interleaved boost converter. It is demonstrated that the combination of reconfiguration strategies promotes remarkable improvements on the post-fault operation of the converter. In addition, an alternative SIMO converter architecture, featuring inherent tolerance against OC faults, is presented and described. To exploit the OC fault tolerance capability of the fault-tolerant SIMO converter, a converter topology targeted at residential LED lighting systems, two alternative reconfiguration strategies are presented and evaluated in detail. Results obtained from computational simulations and experimental tests confirm the effectiveness of the approaches. To further improve the fault-tolerant SIMO converter with regards to its robustness against sensor faults, while simplifying its hardware architecture, a sensorless current control strategy is presented. The proposed control strategy is evaluated resorting to computational simulations.