Based on the 2018 International Joint Conference on Industrial Engineering and Operations Management (IJCIEOM) conference that took place in Lisbon, Portugal, this proceedings volume is the first of two focusing on mathematical applications in digital transformation. The different contributions in this volume explore topics such as health care, social technologies, mathematical programming applications, public transport services, new product development, industry 4.0, occupational safety, quality control, e-services, risk management, and supply chain management. Written by renowned scientists from around the world, this multidisciplinary volume serves as a reference on industrial engineering and operations management and as a source on current findings for researchers and students who focus in business models, digital literacy and technology in education, logistics, production and information systems, and operations management.