This paper presents a methodology that allows the numerical simulation of realistic sea waves, called WaveMIMO methodology, which is based on the imposition of transient discrete data as prescribed velocity on a finite volume computational model developed in Fluent software. These transient data are obtained by using the spectral wave model TOMAWAC, where the wave spectrum is converted into a series of free surface elevations treated and processed as wave propagation velocities in the horizontal (x) and vertical (z) directions. The processed discrete transient data of wave propagation velocity are imposed as boundary conditions of a wave channel in Fluent, allowing the numerical simulation of irregular waves with realistic characteristics. From a case study that reproduces the sea state occurring on March 31st, 2014, in Ingleses Beach, in the city of Florianópolis, state of Santa Catarina, Brazil, it was concluded that the WaveMIMO methodology can properly reproduce realistic conditions of a sea state. In sequence, the proposed methodology was employed to numerically simulate the incidence of irregular realistic waves over an oscillating water column (OWC) wave energy converter (WEC). From these results, the WaveMIMO methodology has proved to be a promising technique to numerically analyze the fluid-dynamic behavior of WECs subjected to irregular waves of realistic sea state on any coastal region where the device can be installed.