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Estudo Geral
Master thesis . 2015
Data sources: Estudo Geral
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Fototerapia: indicações e controvérsias

Authors: Sousa, Pedro José Gomes;

Fototerapia: indicações e controvérsias

Abstract

A fototerapia consiste na utilização de fontes de luz artificial para fins terapêuticos. As quatro modalidades de fototerapia abordadas neste artigo são a UVB convencional, a UVB de banda estreita, a PUVA e a UVA1. Este artigo resultou da revisão de literatura sobre as principais indicações para os tratamentos com fototerapia ou fotoquimoterapia. O seu objetivo foi identificar o papel da fototerapia no tratamento das dermatoses selecionadas. Estas incluem a psoríase, o vitiligo, a dermatite atópica, a micose fungóide e algumas doenças esclerosantes da pele. Neste artigo, foram igualmente abordadas as controvérsias sobre a fototerapia, as quais dizem respeito principalmente ao potencial carcinogénico da mesma, mas também à grande variabilidade de doses e regimes praticados, assim como a falta de estudos sobre o efeito da fototerapia em doentes com fototipos elevados. Concluiu-se que a fototerapia constitui uma abordagem terapêutica eficaz e segura no tratamento destas doenças. Nos doentes tratados com PUVA verificou-se um aumento do risco para desenvolver cancro da pele, mas tal pode ser atenuado com a adoção de medidas preventivas e um seguimento anual. Até ao momento não foi atribuído potencial carcinogénico à radiação UVB em humanos, contrariamente ao que foi observado em modelos animais.

Phototherapy consists in the use of artificial light sources for therapeutic purposes. The four modalities of phototherapy approached in this article are conventional UVB, narrowband UVB, PUVA and UVA1. This article resulted from a review of the literature about the main indications for phototherapy and photocheimotherapy. Its objective was to understand the role of phototherapy in the treatment of the selected dermatosis. These include psoriasis, vitiligo, atopic dermatitis, mycosis fungoides and some sclerotic skin diseases. The controversies about phototherapy, were also approached, mainly its carcinogenic potential, but also the high variability of dosages and regiments practiced and the lack of studies about the effects of phototherapy in patients with high phototypes. We concluded that phototherapy is an effective and safe treatment for selected skin diseases. Patients treated with PUVA are at higher risk of developing skin cancer. This can be mitigated by the implementation of preventive measures and anual follow-up. Until now, unlike observations in animal models, no carcinogenic potential to UVB radiation in humans has been identified.

Trabalho final de mestrado integrado em Medicina (Dermatologia), apresentado à Faculdade de Medicina da Universidade de Coimbra.

Country
Portugal
Related Organizations
Keywords

controvérsias, indicações, fototerapia, UVB, PUVA, cancro da pele

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
Cancer Research