Interaction studies between human α-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2009 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry, volume 17, pages 8,143-8,148 (issn: 0968-0896,

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Authors: López, Gloria V.; Gómez, Luis E.; Campillo, Nuria E.; Páez, Juan A.; Giles, Kaleigh; Atkinson, Jeffrey; González, Mercedes; +2 Authors

doi: 10.1016/j.bmc.2009.10.046

pmid: 19897374

handle: 10261/86584

Interaction studies between human α-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity

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Abstract

Nitric oxide-releasing alpha-tocopherol mimetics with LDL-protective activity were designed to maintain the tocopherol substructure necessary for its biochemical recognition by alpha-tocopherol transfer protein. In order to study the molecular interactions to alpha-TTP, theoretical binding studies by means of docking techniques and experimental binding assays, using a fluorescent probe, were performed. Furoxanyl-tocopherol-hybrid analogs 7 and 9 have the best ability to bind to alpha-TTP suggesting that they could be incorporated to LDL in vivo to further release nitric oxide and prevent oxidative modifications.

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Keywords

Protein Conformation, Molecular Sequence Data, alpha-Tocopherol, Tocopherols, Cholesterol, LDL, Nitric Oxide, Antioxidants, Structure-Activity Relationship, Amino Acid Substitution, Humans, Vitamin E, Nitric Oxide Donors, Protein Binding

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