Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry
Copyright policy )Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry
Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort study.Baseline data from PiZZ individuals, enrolled in the registry with complete data on sex and smoking history were analysed by group comparisons and binary logistic regression analyses.1283 patients with AATD, 49.3% women were analysed. Females reported less tobacco consumption (16.8±12.2 vs. 19.6±14.5 PY, p=0.006), occupational exposures towards gases, dusts or asbestos (p<0.005 each) and consumed less alcohol (5.5±7.6 vs. 8.4±10.3u/week, p<0.001). Females reported COPD (41% vs. 57%, p<0.001) and liver disease (11% vs. 20%, p<0.001) less often. However, they had a higher prevalence of bronchiectasis (24% vs. 13%, p<0.001). Despite better lung function (FEV1%pred. 73.6±29.9 vs. 62.7±29.5, p<0.001) females reported a similar symptom burden (CAT 13.4±9.5 vs. 12.5±8.9, p=ns) and exacerbation frequency (at least one in the previous year 30% vs. 26%, p=ns) compared to males. In multivariate analyses, female sex was an independent risk factor for exacerbations in the previous year OR 1.6 p=0.001 in addition to smoking history, COPD, asthma and bronchiectasis and was also identified as risk factors for symptom burden (CAT≥10) OR 1.4 p=0.014 besides age, BMI, COPD and smoking history.Men had higher rates of COPD and liver disease, women were more likely to have bronchiectasis. Women's higher symptom burden and exacerbation frequency suggest they may need tailored treatment approaches.
- University of Birmingham United Kingdom
- University of Toronto Canada
- University of Zurich Switzerland
- Universitätsklinikum Gießen und Marburg Germany
- German Center for Lung Research Germany
Male, Bronquièctasi - Factors sexuals, Alcohol Drinking, ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica, 610 Medicine & health, ATENCIÓN DE SALUD::calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::factores epidemiológicos::factores sexuales, Comorbidity, DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis, Alfa 1-antitripsina, Pulmonary Disease, Chronic Obstructive, Hàbit de fumar, Sex Factors, alpha 1-Antitrypsin Deficiency, Occupational Exposure, Prevalence, PUBLIC HEALTH::Environmental Health::Occupational Health::Occupational Risks::Smoking, ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::deficiencia de alfa 1-antitripsina, Humans, Prospective Studies, Registries, ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas, Aged, DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive, Pulmons - Malalties obstructives - Factors sexuals, Chronic obstructive pulmonary disease, Liver Diseases, Smoking, ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia, SALUD PÚBLICA::salud ambiental::salud laboral::riesgos profesionales::fumar, Gender, HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors, Middle Aged, Bronchiectasis, 2740 Pulmonary and Respiratory Medicine, DISEASES::Digestive System Diseases::Liver Diseases, Alpha1-antitrypsin, Fetge - Malalties - Factors sexuals, Female, 10178 Clinic for Pneumology, Alpha1-antitrypsin deficiency, DISEASES::Respiratory Tract Diseases::Lung Diseases::alpha 1-Antitrypsin Deficiency
Male, Bronquièctasi - Factors sexuals, Alcohol Drinking, ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica, 610 Medicine & health, ATENCIÓN DE SALUD::calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::factores epidemiológicos::factores sexuales, Comorbidity, DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis, Alfa 1-antitripsina, Pulmonary Disease, Chronic Obstructive, Hàbit de fumar, Sex Factors, alpha 1-Antitrypsin Deficiency, Occupational Exposure, Prevalence, PUBLIC HEALTH::Environmental Health::Occupational Health::Occupational Risks::Smoking, ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::deficiencia de alfa 1-antitripsina, Humans, Prospective Studies, Registries, ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas, Aged, DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive, Pulmons - Malalties obstructives - Factors sexuals, Chronic obstructive pulmonary disease, Liver Diseases, Smoking, ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia, SALUD PÚBLICA::salud ambiental::salud laboral::riesgos profesionales::fumar, Gender, HEALTH CARE::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors, Middle Aged, Bronchiectasis, 2740 Pulmonary and Respiratory Medicine, DISEASES::Digestive System Diseases::Liver Diseases, Alpha1-antitrypsin, Fetge - Malalties - Factors sexuals, Female, 10178 Clinic for Pneumology, Alpha1-antitrypsin deficiency, DISEASES::Respiratory Tract Diseases::Lung Diseases::alpha 1-Antitrypsin Deficiency
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