Maraviroc Clinical Test (MCT) as an alternative tool to decide CCR5-antagonists prescription in naïve HIV-infected patients
Copyright policy )Maraviroc Clinical Test (MCT) as an alternative tool to decide CCR5-antagonists prescription in naïve HIV-infected patients
Our aim was to analyze the virological response to a combined antiretroviral therapy started after Maraviroc Clinical Test (MCT) in naïve HIV-infected patients. Forty-one patients were exposed to MCT, based on an 8-day MVC monotherapy. If undetectability or a viral load reduction >1 log10 HIV-RNA copies/ml was achieved, a MVC-containing cART was prescribed. Forty patients showed a positive MCT; undetectability after 48weeks on cART was achieved in 34/41 (82.9%) patients. The result of MCT was compared with a genotypic tropism method and with Trofile®, showing 10.7% and 18.75% discordance rates, respectively. MCT is a reliable tool to decide CCR5-antagonists prescription, also in the naïve scenario where most patients show a virological response to MVC independently the tropism result reported by genotypic or phenotypic methods.
Adult, Male, Time Factors, Genotype, Genotyping Techniques, Anti-HIV Agents, HIV Infections, Maraviroc, Cyclohexanes, Humans, Viral tropism, Aged, Retrospective Studies, HIV, Naïve, Middle Aged, Triazoles, Viral Load, Viral Tropism, Treatment Outcome, RNA, Viral, Female
Adult, Male, Time Factors, Genotype, Genotyping Techniques, Anti-HIV Agents, HIV Infections, Maraviroc, Cyclohexanes, Humans, Viral tropism, Aged, Retrospective Studies, HIV, Naïve, Middle Aged, Triazoles, Viral Load, Viral Tropism, Treatment Outcome, RNA, Viral, Female
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!