Downloads provided by UsageCountsGenome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Copyright policy )NIH| 1/7 Psychiatric Genomics Consortium: Finding actionable variation ,
NIH| 1/3 Genetic Analysis of the International Cohort Collection for Bipolar Disorder ,
NHMRC| Cognitive enhancement in schizophrenia via selective oestrogen receptor modulator. ,
NIH| Genetic Linkage Studies in Bipolar Disorder Families ,
NHMRC| The biology of risk for bipolar disorder: genetic effects in a high-risk longitudinal study ,
UKRI| The Centre for Neuropsychiatric Genetics and Genomics ,
NIH| Mitochondrial Deletions in Mood Disorders ,
NHMRC| Neurobiological ‘risk’ and ‘resilience’ biomarkers of severe mental illness ,
NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,
NIH| Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder ,
CIHR| unidentified ,
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NIH| Multidimensional Analysis of Synaptic Dysfunction in Schizophrenia ,
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NIH| Big Omics Data Engine 2 Supercomputer ,
NIH| PPHF 2013: OSTLTS Partnerships - CBA of the Public Health System ,
EC| EIMS ,
NIH| 1/4 Psychiatric GWAS Consortium: Genomic Follow-up Next-Gen Seq & Genotyping ,
SNSF| Comprehensive genetic analysis of a series of large families affected with bipolar disorder ,
WT| Genetic dissection of the mood-psychosis spectrum ,
RCN| Integrating analytical tools with brain imaging and genetics in mental illness research and education ,
EC| U-PGx ,
NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,
NHMRC| Using genomics to understand psychiatric disorders ,
WT| unidentified ,
RCN| How do genetic, clinical and treatment factors affect outcome in severe mental disorders? ,
NHMRC| Translating gene discovery for key diseases into clinical outcomes ,
NIH| MOLECULAR GENETICS OF SCHIZOPHRENIA ,
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EC| POSTPARTUM BID ,
NHMRC| Complete genomics for mechanistic insight and precision treatments of schizophrenia ,
RCN| Identifying the missing heritability of complex diseases leveraging biobanks, registries and novel analytical tools in psychiatric disorders ,
NHMRC| Unravelling the genetic causes of bipolar disorder: lessons from rare but highly penetrant variants in very heritable forms of illness ,
NIH| GENERAL CLINICAL RESEARCH CENTER - CAP ,
NIH| 1/5-The Psychiatric GWAS Consortium: Integrated &Coordinated GWAS Meta-Analyses ,
NHMRC| Imaging genetics in schizophrenia and bipolar disorder: Adjudicating neurocognitive endophenotypes ,
NHMRC| Personalised genomics in precision medicine of psychotic illness ,
NHMRC| Research fellowship ,
NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovations ,
NHMRC| Epigenetic mechanisms of brain dysfunction in psychotic and mood disorders
Mullins, Niamh; Forstner, Andreas; O'Connell, Kevin; Coombes, Brandon; Coleman, Jonathan; Qiao, Zhen; Als, Thomas; +193 Authors
Mullins, Niamh; Forstner, Andreas; O'Connell, Kevin; Coombes, Brandon; Coleman, Jonathan; Qiao, Zhen; Als, Thomas; Bigdeli, Tim; Børte, Sigrid; Bryois, Julien; Charney, Alexander; Drange, Ole Kristian; Gandal, Michael; Hagenaars, Saskia; Ikeda, Masashi; Kamitaki, Nolan; Kim, Minsoo; Krebs, Kristi; Panagiotaropoulou, Georgia; Schilder, Brian; Sloofman, Laura; Steinberg, Stacy; Trubetskoy, Vassily; Winsvold, Bendik; Won, Hong-Hee; Abramova, Liliya; Adorjan, Kristina; Agerbo, Esben; Al Eissa, Mariam; Albani, Diego; Alliey-Rodriguez, Ney; Anjorin, Adebayo; Antilla, Verneri; Antoniou, Anastasia; Awasthi, Swapnil; Baek, Ji Hyun; Bækvad-Hansen, Marie; Bass, Nicholas; Bauer, Michael; Beins, Eva; Bergen, Sarah; Birner, Armin; Bøcker Pedersen, Carsten; Bøen, Erlend; Boks, Marco; Bosch, Rosa; Brum, Murielle; Brumpton, Ben; Brunkhorst-Kanaan, Nathalie; Budde, Monika; Bybjerg-Grauholm, Jonas; Byerley, William; Cairns, Murray; Casas, Miquel; Cervantes, Pablo; Clarke, Toni-Kim; Cruceanu, Cristiana; Cuellar-Barboza, Alfredo; Cunningham, Julie; Curtis, David; Czerski, Piotr; Dale, Anders; Dalkner, Nina; David, Friederike; Degenhardt, Franziska; Djurovic, Srdjan; Dobbyn, Amanda; Douzenis, Athanassios; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Ferrier, I Nicol; Fiorentino, Alessia; Foroud, Tatiana; Forty, Liz; Frank, Josef; Frei, Oleksandr; Freimer, Nelson; Frisén, Louise; Gade, Katrin; Garnham, Julie; Gelernter, Joel; Giørtz Pedersen, Marianne; Gizer, Ian; Gordon, Scott; Gordon-Smith, Katherine; Greenwood, Tiffany; Grove, Jakob; Guzman-Parra, José; Ha, Kyooseob; Haraldsson, Magnus; Hautzinger, Martin; Heilbronner, Urs; Hellgren, Dennis; Herms, Stefan; Hoffmann, Per; Holmans, Peter; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica; Kalman, Janos; Kamatani, Yoichiro; Kennedy, James; Kittel-Schneider, Sarah; Knowles, James; Kogevinas, Manolis; Koromina, Maria; Kranz, Thorsten; Kranzler, Henry; Kubo, Michiaki; Kupka, Ralph; Kushner, Steven; Lavebratt, Catharina; Lawrence, Jacob; Leber, Markus; Lee, Heon-Jeong; Lee, Phil; Levy, Shawn; Lewis, Catrin; Liao, Calwing; Lucae, Susanne; Lundberg, Martin; Macintyre, Donald; Magnusson, Sigurdur; Maier, Wolfgang; Maihofer, Adam; Malaspina, Dolores; Maratou, Eirini; Martinsson, Lina; Mattheisen, Manuel; Mccarroll, Steven; Mcgregor, Nathaniel; Mcguffin, Peter; Mckay, James; Medeiros, Helena; Medland, Sarah; Millischer, Vincent; Montgomery, Grant; Moran, Jennifer; Morris, Derek; Mühleisen, Thomas; O'Brien, Niamh; O'Donovan, Claire; Olde Loohuis, Loes; Oruc, Lilijana; Papiol, Sergi; Pardiñas, Antonio; Perry, Amy; Pfennig, Andrea; Porichi, Evgenia; Potash, James; Quested, Digby; Raj, Towfique; Rapaport, Mark; Depaulo, J Raymond; Regeer, Eline; Rice, John; Rivas, Fabio; Rivera, Margarita; Roth, Julian; Roussos, Panos; Ruderfer, Douglas; Sánchez-Mora, Cristina; Schulte, Eva; Senner, Fanny; Sharp, Sally; Shilling, Paul; Sigurdsson, Engilbert; Sirignano, Lea; Slaney, Claire; Smeland, Olav; Smith, Daniel; Sobell, Janet; Søholm Hansen, Christine; Soler Artigas, Maria; Spijker, Anne; Stein, Dan; Strauss, John; Świątkowska, Beata; Terao, Chikashi; Thorgeirsson, Thorgeir; Toma, Claudio; Tooney, Paul; Tsermpini, Evangelia-Eirini; Vawter, Marquis; Vedder, Helmut; Walters, James; Witt, Stephanie; Xi, Simon; Xu, Wei; Yang, Jessica Mei Kay; Young, Allan; Young, Hannah; Zandi, Peter; Zhou, Hang; Zillich, Lea; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Alfredsson, Lars; Babadjanova, Gulja;
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Abstract Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. BD risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating eQTL data implicated 15 genes robustly linked to BD via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of BD subtypes indicated high but imperfect genetic correlation between BD type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of BD, identify novel therapeutic leads and prioritize genes for functional follow-up studies.
France, Poland, United States, Netherlands, France, France, Greece, Italy, Australia, United Kingdom, Australia, United Kingdom, Spain, Germany, Denmark, Germany, United States, Germany
- Indiana University United States
- University of California, San Francisco United States
- Spanish National Research Council Spain
- ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY Canada
- Northwestern University United States
Multifactorial Inheritance, Bipolar Disorder, Major histocompatibility complex, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Medizin, Multifactorial inheritance, Medical and Health Sciences, Genome-wide association studies, Major Histocompatibility Complex/genetics, Major Histocompatibility Complex, Bipolar Disorder; Case-Control Studies; Chromosomes, Human; Genetic Predisposition to Disease; Genome, Human; Humans; Major Histocompatibility Complex; Multifactorial Inheritance; Phenotype; Quantitative Trait Loci; Risk Factors; Genome-Wide Association Study, Risk Factors, HUNT All-In Psychiatry, 2.1 Biological and endogenous factors, Chromosomes, Human, bipolar disorder, info:eu-repo/classification/ddc/570, Genome, Bipolar Disorder/genetics, Biological Sciences, Serious Mental Illness, Mental Illness, Bioinformatics and computational biology, attention deficit hyperactivity disorder, Mental Health, Phenotype, Neurological, Mental health, Biotechnology, Human, 570, Genome-wide association study, Quantitative trait loci, Bipolar disorder, Agricultural biotechnology, Quantitative Trait Loci, 610, Genetic predisposition to disease, Human chromosomes, Chromosomes, Article, SDG 3 - Good Health and Well-being, Genetics, Humans, Genetic Predisposition to Disease, genome, Multifactorial Inheritance/genetics, Genome, Human, case-control studies, Human Genome, Chromosomes, Human/genetics, Brain Disorders, Good Health and Well Being, Psychologie, Case-Control Studies, Quantitative Trait Loci/genetics, Developmental Biology, Genome-Wide Association Study
Multifactorial Inheritance, Bipolar Disorder, Major histocompatibility complex, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Medizin, Multifactorial inheritance, Medical and Health Sciences, Genome-wide association studies, Major Histocompatibility Complex/genetics, Major Histocompatibility Complex, Bipolar Disorder; Case-Control Studies; Chromosomes, Human; Genetic Predisposition to Disease; Genome, Human; Humans; Major Histocompatibility Complex; Multifactorial Inheritance; Phenotype; Quantitative Trait Loci; Risk Factors; Genome-Wide Association Study, Risk Factors, HUNT All-In Psychiatry, 2.1 Biological and endogenous factors, Chromosomes, Human, bipolar disorder, info:eu-repo/classification/ddc/570, Genome, Bipolar Disorder/genetics, Biological Sciences, Serious Mental Illness, Mental Illness, Bioinformatics and computational biology, attention deficit hyperactivity disorder, Mental Health, Phenotype, Neurological, Mental health, Biotechnology, Human, 570, Genome-wide association study, Quantitative trait loci, Bipolar disorder, Agricultural biotechnology, Quantitative Trait Loci, 610, Genetic predisposition to disease, Human chromosomes, Chromosomes, Article, SDG 3 - Good Health and Well-being, Genetics, Humans, Genetic Predisposition to Disease, genome, Multifactorial Inheritance/genetics, Genome, Human, case-control studies, Human Genome, Chromosomes, Human/genetics, Brain Disorders, Good Health and Well Being, Psychologie, Case-Control Studies, Quantitative Trait Loci/genetics, Developmental Biology, Genome-Wide Association Study
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NIH| 1/7 Psychiatric Genomics Consortium: Finding actionable variation, NIH| 1/3 Genetic Analysis of the International Cohort Collection for Bipolar Disorder, NHMRC| Cognitive enhancement in schizophrenia via selective oestrogen receptor modulator., NIH| Genetic Linkage Studies in Bipolar Disorder Families
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