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McGill University

ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Country: Canada

McGill University

28 Projects, page 1 of 6
  • Funder: European Commission Project Code: 294557
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  • Funder: European Commission Project Code: 295735
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  • Funder: European Commission Project Code: 638273
    Overall Budget: 1,436,290 EURFunder Contribution: 1,436,290 EUR

    Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity. Genome-wide chromatin assays have provided insight into the properties and complex architectures by which enhancers regulate genes, but the understanding of their mechanisms is fragmented and their regulatory targets are mostly unknown. Several factors may confound the inference and interpretation of regulatory enhancer activity. There are likely many kinds of regulatory architectures with distinct levels of output and flexibility. Despite this, most state-of-the-art genome-wide studies only consider a single model. In addition, chromatin-based analysis alone does not provide clear insight into function or activity. This project aims to systematically characterize enhancer architectures and delineate what determines their: (1) restricted spatio-temporal activity; (2) robustness to regulatory genetic variation; and (3) dynamic activities over time. My work has shown enhancer transcription to be the most accurate classifier of enhancer activity to date. This data permits unprecedented modeling of regulatory architectures via enhancer-promoter co-expression linking. Careful computational analysis of such data from appropriate experimental systems has a great potential for distinguishing the different modes of regulation and their functional impact. The outcomes have great potential for providing us with new insights into mechanisms of transcriptional regulation. The results will be particularly relevant to interpretation of regulatory genetic variations. Ultimately, knowing the characteristics and conformations of enhancer architectures will increase our ability to link variation in non-coding DNA to phenotypic outcomes like disease susceptibility.

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  • Funder: European Commission Project Code: 613044
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  • Funder: European Commission Project Code: 101093849
    Overall Budget: 2,951,570 EURFunder Contribution: 2,951,570 EUR

    The baby boomers are in the process of retiring. Most are between 60 and 65 when they retire and almost 80% self-assess their health as good. A huge number of research projects has analyzed retirement decisions and the impact of this “pension wave” on the transformation of pension systems in the ageing societies in Europe and elsewhere. There is no lack of pension finance projections and policy advice for pension reforms and their socio-economic effects, including active ageing and the role of elder citizens in transforming our economies into “silver economies”. Much less is known about the second great transformation that will follow the pension wave. In the mid2030s, the health of the baby boomers will have deteriorated and many in these large cohorts will be in need of formal and/or informal long-term care. This “care wave” will transform two generations: the baby boomers in need of care and their children who may supply care. It will have significant implications for labour supply, especially for women, saving behaviour, and therefore for productivity, economic growth and its inclusiveness. The overarching objective of BB-Future is to make a concerted effort to understand the size and the implications of the care wave on economic and social outcomes, to appreciate the quality of this second ageing-related transformation and to develop policy recommendations for advance planning on the EU and MS levels.

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