Synthesis and physicochemical study of collagen hydrophobic derivatives

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1993 Spain English Publisher:American Chemical Society (ACS)Journal:Langmuir, volume 9, pages 3,149-3,153 (issn: 0743-7463, eissn: 1520-5827,

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Authors: Fonseca, María José; Busquets, Antonia; Alsina, M. Asunción; Reig Isart, Francisca;

doi: 10.1021/la00035a066

handle: 10261/332137

Synthesis and physicochemical study of collagen hydrophobic derivatives

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Abstract

Lauryl, hexyl, and succinoyl derivatives of collagen have been synthesized using lauryl/hexyl aldehydes and succinic anhydride as reactants. After chemical characterization, the physicochemical properties of these three collagen derivatives as well as those of the native protein have been studied. The techniques used were ANS and CF fluorescence, surface activity, and surface interaction with monomolecular layers of phospholipids. Hydrophobicity values of these preparations do not follow the expected order according to their substituents. Lauryl collagen shows a break point in its surface activity, indicative of the presence of aggregation. © 1993, American Chemical Society. All rights reserved.

This work wassupported by Grant N.BI092-0982-CG2-02 from CICYT, Spain.

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Spain

Related Organizations

Spanish National Research Council
Spain

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