The high-mountain lakes of Saliencia (El Valle, La Cueva, Calabazosa and Cerveriz), in the Somiedo Natural Park (Asturias, NW Spain), have been subject to different anthropogenic pressures, including metal mining, cattle grazing, damming activities and water channelling work for hydroelectric exploitation. This paper reports the results of a recent geochemical and limnological study conducted in these lakes, for which no previous study existed in the literature. Based on depth profiles of temperature, conductivity, pH and ORP, as well as dissolved oxygen, chlorophyll-a, organic carbon, nutrient and metal concentration, we discuss the impact of anthropogenic pressure on the lakes. In the sampling period (July to September, 2014-2016), most of the lakes showed a marked stratification with vertical gradients as a result of different physical and (bio)geochemical processes. All the lakes showed a good environmental state with no apparent metal pollution. However, this set of mountain lakes is not homogeneous with regard to nutrient availability, primary productivity, or hypolimnetic oxygen deficit and a range of trophic conditions exist from oligotrophic (El Valle) to eutrophic (Calabazosa). This trend shows a good correlation with total phosphorus concentration (e.g., 10 µg/L P in El Valle vs. 35 µg/L P in Calabazosa), though erosive processes in the catchment may also have contributed to increase the oxygen consumption rate through an import of allochthonous organic matter. Higher nitrate contents seem to characterize the areas with higher grazing pressure (e.g., El Valle), though the obtained data do not allow us to establish any evident relationship between cattle activity and eutrophication.