SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes

descriptionPublicationkeyboard_double_arrow_right Article , Preprint 12 Jan 2022 Spain English Publisher:American Society for MicrobiologyJournal:Microbiology Spectrum, volume 10 (eissn: 2165-0497,

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Authors: Brenda Martínez-González; María Eugenia Soria; Lucía Vázquez-Sirvent; Cristina Ferrer-Orta; Rebeca Lobo-Vega; Pablo Mínguez; Lorena de la Fuente; +19 Authors

doi: 10.1128/spectrum.00221-22 , 10.1101/2022.01.10.475768

pmid: 35348367

pmc: PMC9045161

handle: 10261/269505 , 10486/707577

SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes

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Abstract

The study shows that mutant spectra of SARS-CoV-2 from diagnostic samples differ in point mutation abundance and complexity and that significantly larger values were observed in virus from patients who developed mild COVID-19 symptoms. Mutant spectrum complexity is not a uniform trait among isolates. The nature and location of low-frequency amino acid substitutions present in mutant spectra anticipate great potential for phenotypic diversification of SARS-CoV-2.

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Keywords

Diversity index, Ultra-deep sequencing, Medicina, SARS-CoV-2, COVID-19, Spike, Ultradeep sequencing, mutant spectrum, COVID-19 severity, Microbiology, QR1-502, Deletion, diversity index, Mutant spectrum, Nasopharynx, Mutation, Humans, Point Mutation, deletion, mutation, nsp12 (polymerase),, nsp12 (polymerase), Pandemics, Research Article

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