Downloads provided by UsageCountsSynergistic Effect of 3′,4′-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus
Copyright policy ) José Pedro De La Cruz Cortés; Leticia Vallejo-Carmona; María Monsalud Arrebola; Esther Martín-Aurioles; María Dolores Rodriguez-Pérez; Laura Ortega-Hombrados; Cristina Verdugo; +3 Authors
José Pedro De La Cruz Cortés; Leticia Vallejo-Carmona; María Monsalud Arrebola; Esther Martín-Aurioles; María Dolores Rodriguez-Pérez; Laura Ortega-Hombrados; Cristina Verdugo; María África Fernández-Prior; Alejandra Bermúdez-Oria; José Antonio González-Correa;
Synergistic Effect of 3′,4′-Dihidroxifenilglicol and Hydroxytyrosol on Oxidative and Nitrosative Stress and Some Cardiovascular Biomarkers in an Experimental Model of Type 1 Diabetes Mellitus
The objective of this study was to assess a possible synergistic effect of two extra-virgin olive oil polyphenols, 3,4,-dyhydroxyphenylglycol (DHPG) and hydroxytyrosol (HT), in an experimental model of type 1 diabetes. Seven groups of animals were studied: (1) Nondiabetic rats (NDR), (2) 2-month-old diabetic rats (DR), (3) DR treated with 5 mg/kg/day p.o. HT, (4) DR treated with 0.5 mg/kg/day p.o. DHPG, (5) DR treated with 1 mg/kg/day p.o. DHPG, (6) DR treated with HT + DHPG (0.5), (7) DR treated with HT + DHPG (1). Oxidative stress variables (lipid peroxidation, glutathione, total antioxidant activity, 8-isoprostanes, 8-hydroxy-2-deoxyguanosine, and oxidized LDL), nitrosative stress (3-nitrotyrosine), and some cardiovascular biomarkers (platelet aggregation, thromboxane B2, prostacyclin, myeloperoxidase, and vascular cell adhesion protein 1 (VCAM-1)) were analyzed. The diabetic animals showed an imbalance in all of the analyzed variables. HT exerted an antioxidant and downregulatory effect on prothrombotic biomarkers while reducing the fall of prostacyclin. DHPG presented a similar, but quantitatively lower, profile. HT plus DHPG showed a synergistic effect in the reduction of oxidative and nitrosative stress, platelet aggregation, production of prostacyclin, myeloperoxidase, and VCAM-1. This synergism could be important for the development of functional oils enriched in these two polyphenols in the proportion used in this study.
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Platelet Aggregation, 3',4' -dihidroxifenilglicol, Cardiovascular, ,4, oxidative stress, Hydroxytyrosol, Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Eicosanoids::Arachidonic Acids::Thromboxanes::Thromboxane B2, -dihidroxifenilglicol, Olive oils, cardiovascular, Estrés oxidativo, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipid Peroxidation, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical, Aceite de oliva, Medical Subject Headings::Organisms::Eukaryota::Animals, Diabetes mellitus tipo 1, 3′,4′-dihidroxifenilglicol, Medical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Blood Physiological Phenomena::Blood Physiological Processes::Hemorheology::Platelet Aggregation, Phenolic-compounds, hydroxytyrosol, hydroxytyrosol; extra-virgin olive oil polyphenols; 3′,4′-dihidroxifenilglicol; oxidative stress; cardiovascular, Polifenoles, 3, extra-virgin olive oil polyphenols, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1, Vascular Cell Adhesion Molecule-1, RM1-950, Article, Diabetes Mellitus, Experimental, Estrés nitrosativo, Animals, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Cell Adhesion Molecules::Vascular Cell Adhesion Molecule-1, Acetate, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Experimental, Polyphenols, Models, Theoretical, ', Thromboxane B2, Diabetes Mellitus, Type 1, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Polyphenols, Biomarcadores, Oxidative stress, Therapeutics. Pharmacology, Lipid Peroxidation, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Cell Adhesion Molecules, Cell Adhesion Molecules, Extra-virgin olive oil polyphenols
Platelet Aggregation, 3',4' -dihidroxifenilglicol, Cardiovascular, ,4, oxidative stress, Hydroxytyrosol, Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Eicosanoids::Arachidonic Acids::Thromboxanes::Thromboxane B2, -dihidroxifenilglicol, Olive oils, cardiovascular, Estrés oxidativo, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipid Peroxidation, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical, Aceite de oliva, Medical Subject Headings::Organisms::Eukaryota::Animals, Diabetes mellitus tipo 1, 3′,4′-dihidroxifenilglicol, Medical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Blood Physiological Phenomena::Blood Physiological Processes::Hemorheology::Platelet Aggregation, Phenolic-compounds, hydroxytyrosol, hydroxytyrosol; extra-virgin olive oil polyphenols; 3′,4′-dihidroxifenilglicol; oxidative stress; cardiovascular, Polifenoles, 3, extra-virgin olive oil polyphenols, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 1, Vascular Cell Adhesion Molecule-1, RM1-950, Article, Diabetes Mellitus, Experimental, Estrés nitrosativo, Animals, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Cell Adhesion Molecules::Vascular Cell Adhesion Molecule-1, Acetate, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Experimental, Polyphenols, Models, Theoretical, ', Thromboxane B2, Diabetes Mellitus, Type 1, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Polyphenols, Biomarcadores, Oxidative stress, Therapeutics. Pharmacology, Lipid Peroxidation, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Cell Adhesion Molecules, Cell Adhesion Molecules, Extra-virgin olive oil polyphenols
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