Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 18 Sep 2020 Spain English Publisher:MDPI AGJournal:Antioxidants, volume 9, page 885 (eissn: 2076-3921,

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Authors: Álvaro Santana-Garrido; Claudia Reyes-Goya; M. Carmen Pérez-Camino; Helder André; Alfonso Mate; Carmen M. Vázquez;

doi: 10.3390/antiox9090885

pmid: 32961933

pmc: PMC7555058

handle: 10261/220284 , 11441/102953 , 10668/3688

Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

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Abstract

Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree’s counterpart, wild olive (also known in Spain as acebuche—ACE). Here, we aimed to analyze the antioxidant and retinoprotective effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of major and minor compounds present in both oils was accompanied by blood pressure monitoring, morphometric analyses, as well as different determinations of oxidative stress-related parameters in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage.

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Keywords

Medical Subject Headings::Anatomy::Sense Organs::Eye::Retina, Arterial hypertension, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Cardiovascular Agents::Antihypertensive Agents, arterial hypertension, retina, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Protective Agents::Antioxidants, RM1-950, Retina, Article, acebuche, nitric oxide, Hipertensión, oxidative stress, Wild olive oil, Medical Subject Headings::Diseases::Eye Diseases::Ocular Hypertension, Medical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Oleaceae::Olea, Medical Subject Headings::Diseases::Eye Diseases, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Acebuche, Nitric oxide, Medical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements, Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Nitrogen Oxides::Nitric Oxide, NADPH (nicotinamide adenine dinucleotide phosphate) oxidase, Medical Subject Headings::Organisms::Eukaryota::Animals, wild olive oil, Oxidative stress, Therapeutics. Pharmacology, Óxido nítrico, Medical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood Pressure, Estrés Oxidativo

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