Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice

descriptionPublicationkeyboard_double_arrow_right Article 19 Sep 2007 Spain English Publisher:Springer Science and Business Media LLCJournal:Genes & Nutrition, volume 2, pages 111-113 (issn: 1555-8932, eissn: 1865-3499,

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Authors: Bermúdez-Soto, María José; Larrosa, Mar; Garcia-Cantalejo, Jesús M.; Espín de Gea, Juan Carlos; Tomás Barberán, Francisco; García-Conesa, María Teresa;

doi: 10.1007/s12263-007-0026-5

pmid: 18850155

pmc: PMC2474921

handle: 10261/17727

Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice

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Abstract

Berries and red fruits are important dietary sources of polyphenols [1]. In vitro and animal studies have demonstrated the bioavailability and the anti-proliferative and anticarcinogenic properties of these fruits or of their phenolic components [2, 3]. Consumption of berries may contribute to the reduction of colon cancer by mechanisms not yet understood. Gene expression analysis using microarrays allows for a more comprehensive study of the possible molecular mechanisms by which food or food components may prevent certain cancers of the gastrointestinal tract [4]. The aim of this research is to investigate the anti-proliferative effects of a polyphenol-rich berry juice on a human model of colon cancer cells and its association to transcriptional changes in relation to colon cancer.

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Spain

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Keywords

Microarrays, Chokeberry, Polyphenols, Caco-2, Gene expression, Aronia melanocarpa, Colon cancer

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