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handle: 10261/164539
[ES] En este estudio se describe un caso de intoxicación por closantel en una oveja Xalda perteneciente a un rebaño en el que murieron varios animales en junio de 2016. El animal remitido para la necropsia aparecía postrado, con midriasis bilateral y ceguera. Microscópicamente se observó espongiosis intramielínica simétrica y bilateral en la sustancia blanca del cerebro, cerebelo y médula espinal, más intensa en áreas paraventriculares y subpiales. El nervio óptico mostró intenso edema y en la capa granular externa de la retina se observó necrosis de células fotorreceptoras y de sus segmentos, además de vacuolización de la capa de células ganglionares. Una vez comunicados estos resultados al veterinario clínico, éste nos informó que el propietario había desparasitado un lote de 25 ovejas con “Endoex inyectable” y que los síntomas aparecieron a las 24-48 horas, únicamente en los tratados con ese producto y no en un lote de 14 animales que había recibido otro antiparasitario. Los signos clínicos (ataxia, paresia, recumbencia, midriasis y ceguera) y lesiones microscópicas (espongiosis simétrica y bilateral de la sustancia blanca del encéfalo, médula espinal, lesiones del nervio óptico y de la retina) observadas en la necropsia se asocian a toxicidad por closantel.
[EN] A case of toxicity of closantel is described in a Xalda sheep occurred on a farm were some animals died in June 2016. In the sheep submitted for necropsy ataxia, dilated pupils and blindness were noted. Bilateral symmetrical intramyelinic spongiosis of the white matter of the brain and spinal cord adjacent to the lateral ventricles and in subpial location were observed. Edema in the optic nerve and necrosis of the outer nuclear layer and segments and vacuolation of the ganglions cells were evident. We were informed by the clinical veterinarian that the owner administered 25 sheep with Endoex and 24-48 hours after administration of the drug the animals presented the clinical sings. 14 sheep that received other antihelmintic remained normal.
Trabajo presentado al XVIII Congreso Internacional y XLI Congreso Nacional de la Sociedad Española de Ovinotecnia y Caprinotecnia (SEOC). (Salamanca, España, 20-22 septiembre 2017).
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Edema mielínico, Sheep, Ovino, Ceguera, Intramyelinic edema, Blindness, Closantel
Edema mielínico, Sheep, Ovino, Ceguera, Intramyelinic edema, Blindness, Closantel
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