DNA-based nanoscaffolds as vehicles for 5-fluoro-2′-deoxyuridine oligomers in colorectal cancer therapy

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2018 English Publisher:Royal Society of Chemistry (RSC)Journal:Nanoscale, volume 10, pages 7,238-7,249 (issn: 2040-3364, eissn: 2040-3372,

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Authors: A. F. Jorge; A. Aviñó; A. A. C. C. Pais; R. Eritja; C. Fàbrega;

doi: 10.1039/c7nr08442k

pmid: 29632908

handle: 10261/164253

DNA-based nanoscaffolds as vehicles for 5-fluoro-2′-deoxyuridine oligomers in colorectal cancer therapy

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Abstract

A novel application for DNA nanostructures as anticancer drug nanocarriers is proposed. DNA tetrahedron and rectangle DNA origami were exploited to deliver 5-fluoro-2′-deoxyuridine oligomers, aided by cholesterol moieties, into 5-fluorouracil-resistant cancer cells.

Related Organizations

University of Coimbra
Portugal
Spanish National Research Council
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UNIVERSIDADE DE COIMBRA
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Institute of Advanced Chemistry of Catalonia
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UNIVERSIDADE DE COIMBRA
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Keywords

Fluoropyrimidines, DNA nanostructures, DNA, Colorectal cancer, Deoxyuridine, Nanostructures, Cholesterol, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, 5-fluorouracil, Fluorouracil, Colorectal Neoplasms

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