Technology-based entrepreneurship or technopreneurship is the healthy interplay of viable technology ideas, technology skill, and entrepreneurial mindset. It is a significant source of good jobs that create wealth. A shift to this type of entrepreneurship is now being considered by more and more educational institutions worldwide. This study provides a comprehensive picture of mainstreaming technopreneurship in Higher Education Institution (HEI) degree programs. The paper reviewed the educational system attributes to determine the feasibility of mainstreaming technopreneurship. Findings reveal that (a) HEIs educational system often differ dramatically, particularly in terms of accreditation and preferred mainstreaming schemes; and (b) substantial interest among non-business students suggests a welcome opportunity to introduce formally technopreneurship education beyond the stereotype business school.  Keywords: Technopreneurship, mainstreaming, content, context, inputs, outputs, outcome