The present study aimed to verify the effectiveness of saflufenacil herbicide in post-emergence weeds control. Saflufenacil herbicide was applied over Luffa aegyptia, Merremia cissoides, Mucuna aterrima and Ricinus communis weeds, when the plants contained the second pair of true leaves at 0x, 0.25x, 0.5x, 1x, 2x, 4x, 8x with the last one the commercial recommended dose (50 g a.i. ha -1 ). The evaluations of control and plants canopy dry matter mass were conducted at 28 days after treatments application. The experimental design was entirely randomized with four replications. Saflufenacil dose of 50 g a.i. ha -1 controlled satisfactorily M. cissoides, M. aterrima and R. communis . However, L. aegyptiana specie was tolerant when the herbicide was used in the recommended dose. It was possible to conclude that saflufenacil herbicide was effective in controlling M. cissoides, M. aterrima and Ricinus communis but L. aegyptiana specie was tolerant when applied 50 g a.i. ha -1 .