© Sociedad Española de óptica. We present in this paper the quantification of the geometrical features of the anterior segment of the eye using Anterior Segment Optical Coherence Tomography (AS-OCT). This quantification was achieved by following our own developed methodology including the device development and their distortion calibration (Fan and refraction) for 3-D imaging, and automatic analysis tools as well. The stastistical comparison of the corrected topographies of the anterior cornea with topographies from state-of-the art clinical topography systems represents a valuable contribution toward the development >All-OCT-based> topographic systems. In addition, we first reported topographies of the crystalline lens in vivo, which is a promising tool to investigate the lens optical properties, the contribution of the lens to the overall retinal image quality, and understanding the change of the physical properties of the lens with accommodation and aging. Furthermore, our quantitative AS-OCT allowed the analysis of the keratoconic cornea and the changes produced by Intra Corneal Ring Segment (ICRS) treatment, as well as monitoring of the ICRS 3-D location. Finally, OCT-based biometry we present in this paper is a promising tool to investigate the changes after cataract surgery; the contribution of the (Intra Ocular Lens) IOL location and tilt to the overall retinal image quality, and in the design of new IOLs.

This study has been funded by Spanish Government Grant FIS2008-02065 and FIS2011- 25637 and European Grants EURYI-05-102-ES (EURHORCs-ESF) and European Research Council Grant ERC-2011 AdG-294099 to S. Marcos.

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