Hereditary angioedema (HAE) is a syndrome characterized by recurrent angioedema of the skin and mucosa induced by genetic mutations that result in increased bradykinin concentration in the tissues. HAE presents high morbidity and mortality, especially if not adequately treated, since patients live with the risk of having laryngeal angioedema that can lead to death due to asphyxia. Abdominal attacks are also very disabling, and patients often inadvertently undergo exploratory laparotomies. There are approximately 10,000 rare diseases, many of which are [...]