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African Journal of Pharmacy and Pharmacology
Article . 2017 . Peer-reviewed
Data sources: Crossref
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Investigation of antihypertensive effect of Nigerian varieties of Solanum lycopersicon on rats

English
Authors: O. Ani Celestine; O. Augustine Adugba; C. Chinemerem Nworgu; U. Jide Uzoigwe; O. Pamela Okorie; U. Francis Agu; R. Joshua Ediale; +2 Authors

Investigation of antihypertensive effect of Nigerian varieties of Solanum lycopersicon on rats

Abstract

Hypertension remains a global challenge even in the 21st century with attendant increase in mortality rate. The quest for alternative management medications suffixed this investigation using three varieties. Thirty male hypertension induced wistar rats divided into 6 groups of 5 rats each were used. Group A served as the normal control group and was administered 0.9% normal saline as placebo. Group B, C and D were fed with Jos, UTC, Gboko varieties, respectively. Group E was treated with lisinopril at 2.5 mg/kg orally, while group F served as the hypertensive untreated group. Administration lasted for 28 days and all animals were allowed access to food and water ad libitium. Standard methods of non-invasive blood pressure assessment was used to access systolic blood pressure, diastolic blood pressure, heart rate, while the lipid panel was assessed using Cardiocheck test meter (lipidocare) in all the groups. ANOVA was used to analyze data and probability level of p<0.05 considered significant. Results show that rats given Jos and UTC tomatoes performed better as compared to those given Gboko tomatoes but the 3 groups did less well as compared to the Lisinopril group. Groups A and F, the Normotensive and hypertensive controls remained status quo. Groups B and C also did better in having an improvement in the lipid profile, as compared to all the other groups. All these indices put together suggest that the Jos and UTC varieties of tomatoes show a better antihypertensive effect as compared to the Gboko variety and could be used in the management of hypertension owing to the presence of high concentration of antioxidants in them. And if these results are applicable to man, the consumption of Jos and UTC varieties of tomatoes should be encouraged. Key words: Tomatoes, systolic blood pressure, diastolic blood pressure, heart rates, lipid profile.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
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