Diet plays very significant role in maintaining overall health of well being but certain alterations in significant amounts of nutrients can cause various health discomforts among which one is an oxidative compound TMAO (Trimethylamine N Oxide) a metabolite from dietary choline present in many foods and taken as vital nutrient to maintain body vital functions and its deficiency can cause fatality . However its increase in blood serums ie the increase of its metabolite can lead toxic damage thus involve various life threatening diseases like ckd, cardiovascular disease, obesity, metabolic errors and severity to death. The chapter details about choline as a dietary compound and hazards of its metabolites If not consumed in significant way. This emerging micro metabolite lead new trends of studying health complications both in medical and nutritional way.To promote optimal health as well as to approach nutrition goals in holistic way TMAO is a choice of concern. Optimal health at cellular level is the key factor of every diet incorporation. Thus chapter deals with food development enhancing food therapy in considering TMAO based on various investigations and paper researches and its effect on people with or without disease.