“Replant disease” or “replant disorder” may be defined as poor growth response of fruit trees When replanting is done on the same site which previously supported the same or closely related species. It has been reported from different regions of world, wherever the apple is grown (Tewoldemedhin et al., 2011a). The abiotic factors exacerbate the symptoms but the disease seems to have biotic cause (Mazzola,1998). Apple replant disease (ARD) is a disease complex and its etiology is controversial. A multiphasic approach (conventional and molecular) has revealed that ARD is caused by a consortium of microbes like oomycetes (Phytophthora, Pythium), higher fungi (Rhizoctonia, Cylindrocarpon etc.) and nematodes (Pratylenchus) and some may act synergistically (Van Schoor et al., 2008., Tewoldemedhin et al., 2011b). Since ARD is a disease complex, its management has always been a challenging task. The potential hazards of chemical control to human health has necessitated the development of more sustainable measures. Lately, the use of Brassica sp. as green manures in disease management has received great attention. Their use suppresses plant pathogens via release of glucosinolates and manipulating in microbial community composition (Mazzola and Mullinix, 2005). Plant growth promoting rhizobacteria have also been found effective in growth promotion of replanted trees (Bharat, 2011). Pseudomonas putida strain 2 CB isolated from apple roots is reported inhibit the growth of fungal complex responsible replant disease, enhanced growth of M-26 apple root stock in replanted orchards (Mazzola et al., 2002). Hence, the approaches that manipulate resident soil biology and induce soil suppressiveness can be a long-term strategy for ARD management (Mazzola and Manici, 2012). Engineering rhizosphere micro-biome also seems a promising for its management (Winkelmann et al., 2019). Moreover, the tolerant rootstocks like G30 and CG6210 also prove to be the best defence against replant problem. Evalustion of Malus germplasm against apple replant disease may also pave the way in identifying the tolerant genotypes that could be used in breeding programs for producing tolerant clonal rootstocks for replant disease management (Isuta and Merwin,2000., Leinfelder and Merwin,2006).