Citrullus colocynthis (L).schrad (C.Colocynthis), often knownas Colocynth.[FAMILY : Cucurbitaceae]. It is commonlyfound wild in the sandy lands of North West, Punjab and central and Southern India and Coromandal cost. Fruit is Bitter, Pungent and the Fruit are used as a Purgative, anthelmintic, leucoderma, ulcers, asthma etc. Root is useful in Jaundice, ascites, urinary disease, rheumatism.The Pharmacological effects of Root, Fruits, Seeds, Leaves, and the whole CitrullusColocynthis have been practicedfor the treatment of disease. The aim of the study: The present research was undertaken to investigation the Pharmacological activities, Botanical description, Biological sources, Geographical sources, Taxonomic classification, characteristics, Morphological, Nutritional value, Ayurveda and Siddha action. Citrullus colocynthis fruits are containina glycosidees, flavanoids , fatty acids