The article deals with the problem of the return of metaphysics within the framework of the ontological turn of philosophy and the situation of post-metaphysical thinking. The conditions for the possibility of modern metaphysical discourse in the projects of empirical metaphysics and historical ontology are revealed. Historical ontology as a meta-reflexion of philosophy over its own historical foundations is able to bridge the gap between the epistemological static nature of transcendental subjectivity and the ontological dynamism of the growth of scientific knowledge about reality by comprehending the conditions of interaction between science and metaphysics in conditions of post-metaphysical thinking and realistic reversal of ontology. Philosophical knowledge in the context of the ontological turn and the associated return of metaphysics becomes focused not so much on the sharp demarcation of science and metaphysics and postulating the incommensurability of their ontologies, but on identifying mutually enriching areas of research that could give a new impetus to their development.