Cucumber (Cucumis sativus L.) is cultivated throughout the world as an important vegetable. This review offers an insight on the versatile use of cucumbers for cosmetic, culinary and therapeutic purposes. Epidemiological and nutritional studies have shown various benefits associated with the use of cucumber. As cosmetic, cucumber is popularly used for natural beautification and for skin treatments. As a vegetable, cucumber is the quintessential materials and indispensable for salads, soups and smoothie with diverse health benefits including weight loss, remedy for chronic constipation, anti-inflammatory, cardiovascular and cancerous diseases among others. The use including weight loss, cosmetic, culinary and therapeutic purposes.