Ataxia affects the neurological system by impairing balance and motor coordination, which results in significant sensorimotor impairment in both children and adults. Physical activity (PA) has been linked to changes in the structure and functionality of the brain as well as effects on brain plasticity, according to numerous experimental and clinical studies. PA can help with concerns with standing and walking, fine and gross motor function regulation, and muscular tone. This chapter discusses the effects of various training programs on people with ataxia. Exercises that target balance, coordination, and muscular strength include: a) physical activity; b) treadmill training; c) locomotor training on a treadmill; d) trunk stabilization training; e) overground walking for balance; f) intensive exercises; and g) body-controlled videogames (exergames) played at home. Exercise and physical activity must be done frequently to maintain health, wellbeing, and quality of life. The duration and severity of the disease have an impact on how well adapted physical activity works.